ENPP2 promotes progression and lipid accumulation via AMPK/SREBP1/FAS pathway in chronic lymphocytic leukemia

ENPP2 promotes progression and lipid accumulation via AMPK/SREBP1/FAS pathway in chronic lymphocytic leukemia

Abstract Background Disorders of lipid metabolism are critical factors in the progression of chronic lymphocytic leukemia (CLL). However, the characteristics of lipid metabolism and related regulatory mechanisms of CLL remain unclear. Methods Hence, we identified altered metabolites and aberrant lip...

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Bibliographic Details
Main Authors: Liyan Lu, Xinting Hu, Yang Han, Hua Wang, Zheng Tian, Ya Zhang, Xin Wang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cellular & Molecular Biology Letters
Subjects:
Chronic lymphocytic leukemia
Lipidomics
Lipid metabolism
ENPP2
PF-8380
AMPK
Online Access:https://doi.org/10.1186/s11658-024-00675-6
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https://doi.org/10.1186/s11658-024-00675-6

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