Mechanisms and active substances of targeting lipid peroxidation in ferroptosis regulation
Ferroptosis is a novel form of cell death driven by iron-dependent lipid peroxidation and it is implicated in various diseases, such as liver disease, acute kidney injury, cardiovascular disease, neurodegenerative disease and cancer. Lipid-based reactive oxygen species (ROS), particularly lipid hydr...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250204 |
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| author | Hui Chen Lingli Chen Wenjun Wang |
| author_facet | Hui Chen Lingli Chen Wenjun Wang |
| author_sort | Hui Chen |
| collection | DOAJ |
| description | Ferroptosis is a novel form of cell death driven by iron-dependent lipid peroxidation and it is implicated in various diseases, such as liver disease, acute kidney injury, cardiovascular disease, neurodegenerative disease and cancer. Lipid-based reactive oxygen species (ROS), particularly lipid hydroperoxides in the cellular membrane can lead to membrane disruption and cell death mediated by ferroptosis. There are three necessary stages involving in the process of lipid peroxidation regulation in ferroptosis, including the synthesis of membrane phospholipids, initiation of lipid peroxidation and clearance of lipid peroxides. In this review, we summarized the molecular modulation mechanisms of lipid peroxidation in ferroptosis from the above three stages, as well as various ferroptosis modulators targeting lipid peroxidation, including commonly used products, natural bioactive compounds and selenocompounds. Collectively, these findings suggest the vital role of lipid peroxidation in ferroptosis, and targeting lipid peroxidation in ferroptosis is potential to treat ferroptosis-associated diseases. |
| format | Article |
| id | doaj-art-bd20aa83554647d499000387125d121a |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-bd20aa83554647d499000387125d121a2025-01-10T06:56:56ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-09-011352502251810.26599/FSHW.2022.9250204Mechanisms and active substances of targeting lipid peroxidation in ferroptosis regulationHui Chen0Lingli Chen1Wenjun Wang2Jiangxi Key Laboratory of Natural Products and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, ChinaJiangxi Key Laboratory of Natural Products and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, ChinaJiangxi Key Laboratory of Natural Products and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, ChinaFerroptosis is a novel form of cell death driven by iron-dependent lipid peroxidation and it is implicated in various diseases, such as liver disease, acute kidney injury, cardiovascular disease, neurodegenerative disease and cancer. Lipid-based reactive oxygen species (ROS), particularly lipid hydroperoxides in the cellular membrane can lead to membrane disruption and cell death mediated by ferroptosis. There are three necessary stages involving in the process of lipid peroxidation regulation in ferroptosis, including the synthesis of membrane phospholipids, initiation of lipid peroxidation and clearance of lipid peroxides. In this review, we summarized the molecular modulation mechanisms of lipid peroxidation in ferroptosis from the above three stages, as well as various ferroptosis modulators targeting lipid peroxidation, including commonly used products, natural bioactive compounds and selenocompounds. Collectively, these findings suggest the vital role of lipid peroxidation in ferroptosis, and targeting lipid peroxidation in ferroptosis is potential to treat ferroptosis-associated diseases.https://www.sciopen.com/article/10.26599/FSHW.2022.9250204ferroptosislipid peroxidationmechanismsnatural bioactive compoundsselenocompounds |
| spellingShingle | Hui Chen Lingli Chen Wenjun Wang Mechanisms and active substances of targeting lipid peroxidation in ferroptosis regulation Food Science and Human Wellness ferroptosis lipid peroxidation mechanisms natural bioactive compounds selenocompounds |
| title | Mechanisms and active substances of targeting lipid peroxidation in ferroptosis regulation |
| title_full | Mechanisms and active substances of targeting lipid peroxidation in ferroptosis regulation |
| title_fullStr | Mechanisms and active substances of targeting lipid peroxidation in ferroptosis regulation |
| title_full_unstemmed | Mechanisms and active substances of targeting lipid peroxidation in ferroptosis regulation |
| title_short | Mechanisms and active substances of targeting lipid peroxidation in ferroptosis regulation |
| title_sort | mechanisms and active substances of targeting lipid peroxidation in ferroptosis regulation |
| topic | ferroptosis lipid peroxidation mechanisms natural bioactive compounds selenocompounds |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250204 |
| work_keys_str_mv | AT huichen mechanismsandactivesubstancesoftargetinglipidperoxidationinferroptosisregulation AT linglichen mechanismsandactivesubstancesoftargetinglipidperoxidationinferroptosisregulation AT wenjunwang mechanismsandactivesubstancesoftargetinglipidperoxidationinferroptosisregulation |