Establishing cutoff values for visual amyloid positivity in [18F]flutemetamol PET
Abstract Background This study aimed to establish the optimal cutoff values for visual amyloid positivity using standardized uptake value ratios (SUVRs) in [18F]flutemetamol (FMM) positron emission tomography (PET) imaging. Given the variability in amyloid assessment, our goal was to determine cutof...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-01-01
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| Series: | EJNMMI Research |
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| Online Access: | https://doi.org/10.1186/s13550-024-01193-4 |
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| author | Yong-Jin Park So Young Moon Joon-Kee Yoon Su-Jin Lee Young-Sil An |
| author_facet | Yong-Jin Park So Young Moon Joon-Kee Yoon Su-Jin Lee Young-Sil An |
| author_sort | Yong-Jin Park |
| collection | DOAJ |
| description | Abstract Background This study aimed to establish the optimal cutoff values for visual amyloid positivity using standardized uptake value ratios (SUVRs) in [18F]flutemetamol (FMM) positron emission tomography (PET) imaging. Given the variability in amyloid assessment, our goal was to determine cutoff values that enhance diagnostic accuracy and assist clinicians in reliably identifying amyloid positivity. Results The identified cutoff values for visual amyloid positivity were > 1.6 for the cerebellar gray matter, > 1.38 for the whole cerebellum, and > 0.63 for the pons, yielding high sensitivity (95.5%, 94.5%, and 95.8%, respectively) and specificity (91.2%, 94.3%, and 95.2%, respectively). Conclusions The SUVR cutoff values demonstrated excellent diagnostic performance, supporting their clinical use in assessing visual amyloid positivity in [18F]FMM PET imaging. |
| format | Article |
| id | doaj-art-bcd2e5ea11b844b8ab5c9a96e8849caf |
| institution | Kabale University |
| issn | 2191-219X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Research |
| spelling | doaj-art-bcd2e5ea11b844b8ab5c9a96e8849caf2025-01-12T12:39:22ZengSpringerOpenEJNMMI Research2191-219X2025-01-011511710.1186/s13550-024-01193-4Establishing cutoff values for visual amyloid positivity in [18F]flutemetamol PETYong-Jin Park0So Young Moon1Joon-Kee Yoon2Su-Jin Lee3Young-Sil An4Department of Nuclear Medicine and Molecular Imaging, Ajou University School of MedicineDepartment of Neurology, Ajou University School of MedicineDepartment of Nuclear Medicine and Molecular Imaging, Ajou University School of MedicineDepartment of Nuclear Medicine and Molecular Imaging, Ajou University School of MedicineDepartment of Nuclear Medicine and Molecular Imaging, Ajou University School of MedicineAbstract Background This study aimed to establish the optimal cutoff values for visual amyloid positivity using standardized uptake value ratios (SUVRs) in [18F]flutemetamol (FMM) positron emission tomography (PET) imaging. Given the variability in amyloid assessment, our goal was to determine cutoff values that enhance diagnostic accuracy and assist clinicians in reliably identifying amyloid positivity. Results The identified cutoff values for visual amyloid positivity were > 1.6 for the cerebellar gray matter, > 1.38 for the whole cerebellum, and > 0.63 for the pons, yielding high sensitivity (95.5%, 94.5%, and 95.8%, respectively) and specificity (91.2%, 94.3%, and 95.2%, respectively). Conclusions The SUVR cutoff values demonstrated excellent diagnostic performance, supporting their clinical use in assessing visual amyloid positivity in [18F]FMM PET imaging.https://doi.org/10.1186/s13550-024-01193-4AmyloidPositron emission tomographyFlutemetamolCutoffCortexID suite |
| spellingShingle | Yong-Jin Park So Young Moon Joon-Kee Yoon Su-Jin Lee Young-Sil An Establishing cutoff values for visual amyloid positivity in [18F]flutemetamol PET EJNMMI Research Amyloid Positron emission tomography Flutemetamol Cutoff CortexID suite |
| title | Establishing cutoff values for visual amyloid positivity in [18F]flutemetamol PET |
| title_full | Establishing cutoff values for visual amyloid positivity in [18F]flutemetamol PET |
| title_fullStr | Establishing cutoff values for visual amyloid positivity in [18F]flutemetamol PET |
| title_full_unstemmed | Establishing cutoff values for visual amyloid positivity in [18F]flutemetamol PET |
| title_short | Establishing cutoff values for visual amyloid positivity in [18F]flutemetamol PET |
| title_sort | establishing cutoff values for visual amyloid positivity in 18f flutemetamol pet |
| topic | Amyloid Positron emission tomography Flutemetamol Cutoff CortexID suite |
| url | https://doi.org/10.1186/s13550-024-01193-4 |
| work_keys_str_mv | AT yongjinpark establishingcutoffvaluesforvisualamyloidpositivityin18fflutemetamolpet AT soyoungmoon establishingcutoffvaluesforvisualamyloidpositivityin18fflutemetamolpet AT joonkeeyoon establishingcutoffvaluesforvisualamyloidpositivityin18fflutemetamolpet AT sujinlee establishingcutoffvaluesforvisualamyloidpositivityin18fflutemetamolpet AT youngsilan establishingcutoffvaluesforvisualamyloidpositivityin18fflutemetamolpet |