Effect of plasma lipoprotein-associated phospholipase A<sub>2</sub> levels on structure and function of heart in patients undergoing maintenance hemodialysis

Effect of plasma lipoprotein-associated phospholipase A<sub>2</sub> levels on structure and function of heart in patients undergoing maintenance hemodialysis

Objective To investigate the clinical application of plasma lipoprotein-associated phospholipase phospholipaseA<sub>2</sub>（Lp-PLA<sub>2</sub>） levels in evaluation of structure and function of heart in patients undergoing maintenance hemodialysis（MHD）.Methods Seventy MHD pat...

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Bibliographic Details
Main Authors: WANG Yun-qian, CHEN Bao-ping, SHI Jun
Format: Article
Language:zho
Published: Editorial Department of Journal of Clinical Nephrology 2016-01-01
Series:Linchuang shenzangbing zazhi
Subjects:
Maintenance hemodialysis
Lipoprotein-associated phospholipaseA2
Heart
Structure
Function
Online Access:http://www.lcszb.com/thesisDetails?columnId=57919831&Fpath=home&index=0
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Summary:Objective To investigate the clinical application of plasma lipoprotein-associated phospholipase phospholipaseA<sub>2</sub>（Lp-PLA<sub>2</sub>） levels in evaluation of structure and function of heart in patients undergoing maintenance hemodialysis（MHD）.Methods Seventy MHD patients were involved in the study,who were treated with MHD for at least 6 months before the study and in a stable clinical status.The plasma Lp-PLA<sub>2</sub> levels were examined by ELISA.The serum B-type natriuretic peptide（BNP） levels were measured by immunofluorescent assay.The parameters of left ventricular end-diastolic diameter（LVEDD）,left atrial diameter（LAD）,left ventricular posterior wall depth（LVPWD） and left ventricular ejection fraction（LVEF） were measured by cardiac color ultrasound,the left ventricular mass index(LVMD was calculated,and the relationship between plasma Lp-PLA<sub>2</sub> levels and parameters determined by cardiac color ultrasound was analyzed.Another 40 healthy volunteers served as normal control group.Results（1） The levels of Lp-PLA<sub>2</sub>,BNP,LVMI,LVEF and systolic pressure in MHD group were significantly higher than those in normal control group（P<0.05）.（2） In MHD group,the patients with abnormal LVEF（LVEF<50%）,left ventricle hypertrophy and/or cardiac insufficiency（BNP>300 ng/L） had higher levels of Lp-PLA<sub>2</sub> than the other patients without abnormal LVEF（LVEF>50%）,left ventricle hypertrophy and/or cardiac sufficiency（BNP<300 ng/L）.（3） The plasma Lp-PLA<sub>2</sub> level was positively correlated with the levels of BNP（r =0.43,P<0.05） and LVMI（r = 0.58,P<0.01）,but negatively with the level of LVEF（r =- 0.67,P<0.01） in patients undergoing MHD.（4） Multiple stepwise regression analysis demonstrated that the plasmaLp-PLA<sub>2</sub> level was correlated with the levels of LVMI（β=0.342,P<0.01）and LVEF（β=- 0.396,P<0.01）.Conclusions Higher plasma Lp-PLA<sub>2</sub> levels extensively exists in patients undergoing MHD.Plasma Lp-PLA<sub>2</sub> level can reflect structure and function of left ventricle,which may play an important role in the evaluation of left ventricular hypertrophy and function of left ventricle.
ISSN:1671-2390

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