Tertiary lymphoid structures in the microenvironment of colorectal cancer: exploring new therapeutic targets

Abstract Immunotherapy has shown limited efficacy in colorectal cancer (CRC), necessitating the urgent identification of novel immunotherapeutic targets to address this challenge. Tertiary lymphoid structures (TLSs) are complex immune structures that spontaneously form within and outside of the tumo...

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Bibliographic Details
Main Authors: Nan-Nan Dai, Man-Yi Hu, Jian-Ping Wang, Zhi-Hui Dai, Li Xu, Tai-Wei Ye
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cancer Immunology, Immunotherapy
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Online Access:https://doi.org/10.1007/s00262-025-04108-x
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