Anti-breast cancer effects of dairy protein active peptides, dairy products, and dairy protein-based nanoparticles
Breast cancer is the most frequently diagnosed and fatal cancer among women worldwide. Dairy protein-derived peptides and dairy products are important parts of the daily human diet and have shown promising activities in suppressing the proliferation, migration, and invasion of breast cancer cells, b...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1486264/full |
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| author | Deju Zhang Deju Zhang Deju Zhang Ying Yuan Ying Yuan Juan Xiong Juan Xiong Qingdong Zeng Qingdong Zeng Yiming Gan Kai Jiang Ni Xie |
| author_facet | Deju Zhang Deju Zhang Deju Zhang Ying Yuan Ying Yuan Juan Xiong Juan Xiong Qingdong Zeng Qingdong Zeng Yiming Gan Kai Jiang Ni Xie |
| author_sort | Deju Zhang |
| collection | DOAJ |
| description | Breast cancer is the most frequently diagnosed and fatal cancer among women worldwide. Dairy protein-derived peptides and dairy products are important parts of the daily human diet and have shown promising activities in suppressing the proliferation, migration, and invasion of breast cancer cells, both in vitro and in vivo. Most of the review literature employs meta-analysis methods to explore the association between dairy intake and breast cancer risk. However, there is a lack of comprehensive summary regarding the anti-breast cancer properties of dairy protein-derived peptides, dairy products, and dairy protein-based nanoparticles as well as their underlying mechanisms of action. Therefore, the present study discussed the breast cancer inhibitory effects and mechanisms of active peptides derived from various dairy protein sources. Additionally, the characteristics, anti-breast cancer activities and active components of several types of dairy products, including fermented milk, yogurt and cheeses, were summarized. Furthermore, the preparation methods and therapeutic effects of various dairy protein-containing nanoparticle delivery systems for breast cancer therapy were briefly described. Lastly, this work also provided an overview of what is currently known about the anti-breast cancer effects of dairy products in clinical studies. Our review will be of interest to the development of natural anticancer drugs. |
| format | Article |
| id | doaj-art-bc7e64f021304a6e9c40d6bd004d51e2 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-bc7e64f021304a6e9c40d6bd004d51e22024-11-13T04:58:51ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-11-011510.3389/fphar.2024.14862641486264Anti-breast cancer effects of dairy protein active peptides, dairy products, and dairy protein-based nanoparticlesDeju Zhang0Deju Zhang1Deju Zhang2Ying Yuan3Ying Yuan4Juan Xiong5Juan Xiong6Qingdong Zeng7Qingdong Zeng8Yiming Gan9Kai Jiang10Ni Xie11Biobank, Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, ChinaGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, ChinaFood and Nutritional Sciences, School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, ChinaBiobank, Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, ChinaGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, ChinaBiobank, Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, ChinaHengyang Medical School, University of South China, Hengyang, Hunan, ChinaBiobank, Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, ChinaHengyang Medical School, University of South China, Hengyang, Hunan, ChinaPlant Science, School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, ChinaEastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo, Zhejiang, ChinaBiobank, Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, ChinaBreast cancer is the most frequently diagnosed and fatal cancer among women worldwide. Dairy protein-derived peptides and dairy products are important parts of the daily human diet and have shown promising activities in suppressing the proliferation, migration, and invasion of breast cancer cells, both in vitro and in vivo. Most of the review literature employs meta-analysis methods to explore the association between dairy intake and breast cancer risk. However, there is a lack of comprehensive summary regarding the anti-breast cancer properties of dairy protein-derived peptides, dairy products, and dairy protein-based nanoparticles as well as their underlying mechanisms of action. Therefore, the present study discussed the breast cancer inhibitory effects and mechanisms of active peptides derived from various dairy protein sources. Additionally, the characteristics, anti-breast cancer activities and active components of several types of dairy products, including fermented milk, yogurt and cheeses, were summarized. Furthermore, the preparation methods and therapeutic effects of various dairy protein-containing nanoparticle delivery systems for breast cancer therapy were briefly described. Lastly, this work also provided an overview of what is currently known about the anti-breast cancer effects of dairy products in clinical studies. Our review will be of interest to the development of natural anticancer drugs.https://www.frontiersin.org/articles/10.3389/fphar.2024.1486264/fullmilk-derived peptidesbreast cancernanoparticlesapoptosisantibreast cancer |
| spellingShingle | Deju Zhang Deju Zhang Deju Zhang Ying Yuan Ying Yuan Juan Xiong Juan Xiong Qingdong Zeng Qingdong Zeng Yiming Gan Kai Jiang Ni Xie Anti-breast cancer effects of dairy protein active peptides, dairy products, and dairy protein-based nanoparticles Frontiers in Pharmacology milk-derived peptides breast cancer nanoparticles apoptosis antibreast cancer |
| title | Anti-breast cancer effects of dairy protein active peptides, dairy products, and dairy protein-based nanoparticles |
| title_full | Anti-breast cancer effects of dairy protein active peptides, dairy products, and dairy protein-based nanoparticles |
| title_fullStr | Anti-breast cancer effects of dairy protein active peptides, dairy products, and dairy protein-based nanoparticles |
| title_full_unstemmed | Anti-breast cancer effects of dairy protein active peptides, dairy products, and dairy protein-based nanoparticles |
| title_short | Anti-breast cancer effects of dairy protein active peptides, dairy products, and dairy protein-based nanoparticles |
| title_sort | anti breast cancer effects of dairy protein active peptides dairy products and dairy protein based nanoparticles |
| topic | milk-derived peptides breast cancer nanoparticles apoptosis antibreast cancer |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1486264/full |
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