Unveiling the substrate specificity of the ABC transporter Tba and its role in glycopeptide biosynthesis

Unveiling the substrate specificity of the ABC transporter Tba and its role in glycopeptide biosynthesis

Summary: Glycopeptide antibiotics (GPA) such as vancomycin are essential last-resort antibiotics produced by actinomycetes. Their biosynthesis is encoded within biosynthetic gene clusters, also harboring genes for regulation, and transport. Diverse types of GPAs have been characterized that differ i...

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Main Authors: Nicola Gericke, Dardan Beqaj, Thales Kronenberger, Andreas Kulik, Athina Gavriilidou, Mirita Franz-Wachtel, Ulrich Schoppmeier, Theresa Harbig, Johanna Rapp, Iwan Grin, Nadine Ziemert, Hannes Link, Kay Nieselt, Boris Macek, Wolfgang Wohlleben, Evi Stegmann, Samuel Wagner
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:iScience
Subjects:
Biosynthesis
Biochemistry
Chemical synthesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225003955
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