Cell-specific Nav1.6 knockdown reduced astrocyte-derived Aβ by reverse Na+-Ca2+ transporter-mediated autophagy in alzheimer-like mice

Cell-specific Nav1.6 knockdown reduced astrocyte-derived Aβ by reverse Na+-Ca2+ transporter-mediated autophagy in alzheimer-like mice

Introduction: Nav1.6 is closely related to the pathology of Alzheimer’s Disease (AD), and astrocytes have recently been identified as a significant source of β-amyloid (Aβ). However, little is known about the connection between Nav1.6 and astrocyte-derived Aβ. Objective: This study explored the cruc...

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Main Authors: Xin Wang, Wei Wu, Guang Yang, Xue-Wei Yang, Xu Ma, Dan-Dan Zhu, Kabir Ahmad, Khizar Khan, Ying-Zi Wang, Ao-Ran Sui, Song-Yu Guo, Yue Kong, Bo Yuan, Tian-Yuan Luo, Cheng-Kang Liu, Peng Zhang, Yue Zhang, Qi-Fa Li, Bin Wang, Qiong Wu, Xue-Fei Wu, Zhi-Cheng Xiao, Quan-Hong Ma, Shao Li
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Advanced Research
Subjects:
Alzheimer’s disease
Sodium channels Nav1.6
Astrocytes
β-amyloid
Amyloid precursor protein
Autophagy-lysosome pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224003096
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