Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients

Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients

Abstract Intestinal tuft cells are epithelial sentinels that trigger host defense upon detection of parasite-derived compounds. While they represent potent targets for immunomodulatory therapies in inflammation-driven intestinal diseases, their functioning and differentiation are poorly understood....

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Main Authors: Julian R. Buissant des Amorie, Max A. Betjes, Jochem H. Bernink, Joris H. Hageman, Veerle E. Geurts, Harry Begthel, Dimitrios Laskaris, Maria C. Heinz, Ingrid Jordens, Tiba Vinck, Ronja M. Houtekamer, Ingrid Verlaan-Klink, Sascha R. Brunner, Jacco van Rheenen, Martijn Gloerich, Hans Clevers, Sander J. Tans, Jeroen S. van Zon, Hugo J. G. Snippert
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61878-9
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