A novel C-3-substituted oleanolic acid benzyl amide derivative exhibits therapeutic potential against influenza A by targeting PA–PB1 interactions and modulating host macrophage inflammation

A novel C-3-substituted oleanolic acid benzyl amide derivative exhibits therapeutic potential against influenza A by targeting PA–PB1 interactions and modulating host macrophage inflammation

The influenza A virus (IAV), renowned for its high contagiousness and potential to catalyze global pandemics, poses significant challenges due to the emergence of drug-resistant strains. Given the critical role of RNA polymerase in IAV replication, it stands out as a promising target for anti-IAV th...

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Bibliographic Details
Main Authors: Kunyu Lu, Jianfu He, Chongjun Hong, Haowei Li, Jiaai Ruan, Jinshen Wang, Haoxing Yuan, Binhao Rong, Chan Yang, Gaopeng Song, Shuwen Liu
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Influenza A virus
RNA polymerase
Protein–protein interaction
Pentacyclic triterpenoids
Oleanolic acid amide derivatives
Drug-resistant strains
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352500365X
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