Acid sphingomyelinase promotes diabetic cardiomyopathy via disruption of mitochondrial calcium homeostasis

Acid sphingomyelinase promotes diabetic cardiomyopathy via disruption of mitochondrial calcium homeostasis

Abstract Background Impaired Ca2+ handling is involved in diabetic cardiomyopathy (DCM) progression. The activation of acid sphingomyelinase (ASMase) stimulated cardiomyocytes apoptosis and caused DCM. Here, we aimed to investigate whether ASMase regulates mitochondrial Ca2+ homeostasis by acting on...

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Bibliographic Details
Main Authors: Yu Wei, Yang Ji, Jiahui Meng, Li Yu, Yongzhong Tang, Wei-Jin Fang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cardiovascular Diabetology
Subjects:
Diabetic cardiomyopathy
ASMase
Mitochondrial calcium homeostasis
MICU1
Online Access:https://doi.org/10.1186/s12933-025-02801-w
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