Evaluation of the effect of co-transplantation of collagen-hydroxyapatite bio-scaffold containing nanolycopene and human endometrial mesenchymal stem cell derived exosomes to regenerate bone in rat critical size calvarial defect

Evaluation of the effect of co-transplantation of collagen-hydroxyapatite bio-scaffold containing nanolycopene and human endometrial mesenchymal stem cell derived exosomes to regenerate bone in rat critical size calvarial defect

This study aimed to evaluate the effect of nanoparticles based on the PLGA and biomolecule of lycopene (i.e. NLcp) and exosomes loaded on hydroxyapatite/collagen-based scaffolds (HA/Coll), on human endometrial MSCs (hEnMSCs) differentiation into osteoblast cells. To this end, after synthesizing NLcp...

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Main Authors: Masoumeh Einabadi, Azadeh Izadyari Aghmiuni, Laleh Foroutani, Arman Ai, Mojdeh Salehi Namini, Ali Farzin, Amir Nahanmoghadam, Sadegh Shirian, Hossein Kargar Jahromi, Jafar Ai
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Regenerative Therapy
Subjects:
Lycopene nanoparticles
Biomolecules
Exosome
Bone tissue-engineered scaffold
Skull-defect model
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320424000208
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