The manipulator behind “Scissors”: γ -secretase and its modulators in Alzheimer’s disease

The manipulator behind “Scissors”: γ -secretase and its modulators in Alzheimer’s disease

The intramembrane aspartic protease, γ-secretase, is a heterotetrameric protein complex composed of four integral membrane proteins: presenilin (PSEN), nicastrin (NCT), Anterior pharynx defective-1 (APH-1), and presenilin enhancer 2 (PEN-2). These components are sequentially assembled into a functio...

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Bibliographic Details
Main Authors: Gao Ning, Xing Fan, Du Juan, Zhao wenxue, Wang Sijia, Chen Meinei, Dong Xiaolong, Qi Yiming
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
γ-secretase
Alzheimer’s disease
GSMS
GSMPs
type I transmembrane proteins
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1637671/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2025.1637671/full

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