Enhanced triacylglycerol metabolism contributes to the efficient biosynthesis of spinosad in Saccharopolyspora spinosa

Enhanced triacylglycerol metabolism contributes to the efficient biosynthesis of spinosad in Saccharopolyspora spinosa

Triacylglycerol (TAG) is crucial for antibiotic biosynthesis derived from Streptomyces, as it serves as an important carbon source. In this study, the supplementation of exogenous TAG led to a 3.92-fold augmentation in spinosad production. The impact of exogenous TAG on the metabolic network of Sacc...

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Bibliographic Details
Main Authors: Li Cao, Yangchun Liu, Lin Sun, Zirong Zhu, Danlu Yang, Ziyuan Xia, Duo Jin, Zirui Dai, Jie Rang, Liqiu Xia
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-12-01
Series:Synthetic and Systems Biotechnology
Subjects:
Saccharopolyspora spinosa
Spinosad
Triacylglycerol
Lipase
Acyl-CoAs
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X24000966
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http://www.sciencedirect.com/science/article/pii/S2405805X24000966

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