IgM+IgD− B cells in human gut-associated lymphoid tissue have memory features and give rise to IgM+ and IgA+ antibody-secreting cells

IgM+IgD− B cells in human gut-associated lymphoid tissue have memory features and give rise to IgM+ and IgA+ antibody-secreting cells

Abstract Human IgM+ B cells vary in their surface levels of IgD, with the major circulating population of IgM+IgD+ cells and a minor population (< 5%) of IgM+IgD− cells. In contrast, in gut-associated lymphoid tissue (GALT) derived from individuals undergoing tonsillectomy or appendectomy, IgM+Ig...

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Bibliographic Details
Main Authors: Ameera M. Bukhari, Wenzhao Meng, Aaron M. Rosenfeld, Eline T. Luning Prak, Katherine L. Knight
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Gut-associated lymphoid tissue (GALT)
B cells
IgM+ B cells
Somatic hypermutation (SHM)
Memory B cells
Class-switching
Online Access:https://doi.org/10.1038/s41598-025-11209-1
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https://doi.org/10.1038/s41598-025-11209-1

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