Involvement of sphingosine-1-phosphate receptor 1 in pain insensitivity in a BTBR mouse model of autism spectrum disorder

Involvement of sphingosine-1-phosphate receptor 1 in pain insensitivity in a BTBR mouse model of autism spectrum disorder

Abstract Background Abnormal sensory perception, particularly pain insensitivity (PAI), is a typical symptom of autism spectrum disorder (ASD). Despite the role of myelin metabolism in the regulation of pain perception, the mechanisms underlying ASD-related PAI remain unclear. Methods The pain-assoc...

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Bibliographic Details
Main Authors: Lili Fan, Qi Li, Yaxin Shi, Xiang Li, Yutong Liu, Jiaqi Chen, Yaqi Sun, Anjie Chen, Yuan Yang, Xirui Zhang, Jia Wang, Lijie Wu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Medicine
Subjects:
Pain insensitivity
Autism spectrum disorder
BTBR model mice
Sphingosine-1-phosphate
KCNQ/M potassium channels
Online Access:https://doi.org/10.1186/s12916-024-03722-3
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https://doi.org/10.1186/s12916-024-03722-3

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