Estimation and Correlation of Clinical Significance of Lipoprotein (a) as a Risk Factor of Atherosclerotic Vascular Events in Elderly: A 1-year Cross-sectional Study in KLE’s Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi
Introduction: Lipoprotein (a) (Lp(a)) was identified as a variant of low-density lipoprotein (LDL) 40 years ago. Lp(a) consists of one LDL particle containing apoB-100 and one molecule of a large, highly polymorphic glycoprotein known as apo (a). The study aimed to evaluate and correlate the clinica...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of the Scientific Society |
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| Online Access: | https://journals.lww.com/10.4103/jss.jss_183_24 |
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| author | Yashoda Tushar Maladkar Veerappa Annasaheb Kothiwale |
| author_facet | Yashoda Tushar Maladkar Veerappa Annasaheb Kothiwale |
| author_sort | Yashoda Tushar Maladkar |
| collection | DOAJ |
| description | Introduction:
Lipoprotein (a) (Lp(a)) was identified as a variant of low-density lipoprotein (LDL) 40 years ago. Lp(a) consists of one LDL particle containing apoB-100 and one molecule of a large, highly polymorphic glycoprotein known as apo (a). The study aimed to evaluate and correlate the clinical significance of Lp(a) as a risk factor for atherosclerotic vascular events in the elderly population.
Materials and Methods:
This cross-sectional study was conducted among patients admitted in a tertiary care hospital for for 1 year. One hundred and forty-two study participants included in the study were divided into two groups atherosclerotic vascular event group (2 subgroups: Cardiovascular atherosclerotic vascular event subgroup and neurological atherosclerotic vascular event subgroup) and no atherosclerotic vascular event group. Detailed history, examination, and parameters such as serum Lp(a), serum high-density lipoproteins, LDL, total cholesterol, triglycerides, glycated hemoglobin, and creatinine were tested.
Results:
Among 142 study participants in the study, majority of study participants were male (n = 96, 67.6%). The mean age was 71.63 years. High Lp(a) levels were noted in 51.41% of study participants. High Lp(a) levels were seen in 56% of study participants in the cardiovascular atherosclerotic vascular event subgroup, 43.33% of study participants in the neurological atherosclerotic vascular event subgroup and 51.61% in no atherosclerotic vascular event group.
Conclusion:
Our study concludes that Lp(a) may not be used to infer any clinical significance, nor may it have any role to play as a risk factor for atherosclerotic vascular events in the elderly (age >65 years). |
| format | Article |
| id | doaj-art-ba04283f47254325902826e1f850a971 |
| institution | Kabale University |
| issn | 0974-5009 2278-7127 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Scientific Society |
| spelling | doaj-art-ba04283f47254325902826e1f850a9712025-01-07T07:23:01ZengWolters Kluwer Medknow PublicationsJournal of the Scientific Society0974-50092278-71272024-12-0151455956510.4103/jss.jss_183_24Estimation and Correlation of Clinical Significance of Lipoprotein (a) as a Risk Factor of Atherosclerotic Vascular Events in Elderly: A 1-year Cross-sectional Study in KLE’s Dr. Prabhakar Kore Hospital and Medical Research Centre, BelagaviYashoda Tushar MaladkarVeerappa Annasaheb KothiwaleIntroduction: Lipoprotein (a) (Lp(a)) was identified as a variant of low-density lipoprotein (LDL) 40 years ago. Lp(a) consists of one LDL particle containing apoB-100 and one molecule of a large, highly polymorphic glycoprotein known as apo (a). The study aimed to evaluate and correlate the clinical significance of Lp(a) as a risk factor for atherosclerotic vascular events in the elderly population. Materials and Methods: This cross-sectional study was conducted among patients admitted in a tertiary care hospital for for 1 year. One hundred and forty-two study participants included in the study were divided into two groups atherosclerotic vascular event group (2 subgroups: Cardiovascular atherosclerotic vascular event subgroup and neurological atherosclerotic vascular event subgroup) and no atherosclerotic vascular event group. Detailed history, examination, and parameters such as serum Lp(a), serum high-density lipoproteins, LDL, total cholesterol, triglycerides, glycated hemoglobin, and creatinine were tested. Results: Among 142 study participants in the study, majority of study participants were male (n = 96, 67.6%). The mean age was 71.63 years. High Lp(a) levels were noted in 51.41% of study participants. High Lp(a) levels were seen in 56% of study participants in the cardiovascular atherosclerotic vascular event subgroup, 43.33% of study participants in the neurological atherosclerotic vascular event subgroup and 51.61% in no atherosclerotic vascular event group. Conclusion: Our study concludes that Lp(a) may not be used to infer any clinical significance, nor may it have any role to play as a risk factor for atherosclerotic vascular events in the elderly (age >65 years).https://journals.lww.com/10.4103/jss.jss_183_24cardiovascular atherosclerotic vascular eventlipid profilelipoprotein (a)neurological atherosclerotic vascular event |
| spellingShingle | Yashoda Tushar Maladkar Veerappa Annasaheb Kothiwale Estimation and Correlation of Clinical Significance of Lipoprotein (a) as a Risk Factor of Atherosclerotic Vascular Events in Elderly: A 1-year Cross-sectional Study in KLE’s Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi Journal of the Scientific Society cardiovascular atherosclerotic vascular event lipid profile lipoprotein (a) neurological atherosclerotic vascular event |
| title | Estimation and Correlation of Clinical Significance of Lipoprotein (a) as a Risk Factor of Atherosclerotic Vascular Events in Elderly: A 1-year Cross-sectional Study in KLE’s Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi |
| title_full | Estimation and Correlation of Clinical Significance of Lipoprotein (a) as a Risk Factor of Atherosclerotic Vascular Events in Elderly: A 1-year Cross-sectional Study in KLE’s Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi |
| title_fullStr | Estimation and Correlation of Clinical Significance of Lipoprotein (a) as a Risk Factor of Atherosclerotic Vascular Events in Elderly: A 1-year Cross-sectional Study in KLE’s Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi |
| title_full_unstemmed | Estimation and Correlation of Clinical Significance of Lipoprotein (a) as a Risk Factor of Atherosclerotic Vascular Events in Elderly: A 1-year Cross-sectional Study in KLE’s Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi |
| title_short | Estimation and Correlation of Clinical Significance of Lipoprotein (a) as a Risk Factor of Atherosclerotic Vascular Events in Elderly: A 1-year Cross-sectional Study in KLE’s Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi |
| title_sort | estimation and correlation of clinical significance of lipoprotein a as a risk factor of atherosclerotic vascular events in elderly a 1 year cross sectional study in kle s dr prabhakar kore hospital and medical research centre belagavi |
| topic | cardiovascular atherosclerotic vascular event lipid profile lipoprotein (a) neurological atherosclerotic vascular event |
| url | https://journals.lww.com/10.4103/jss.jss_183_24 |
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