A Case of Hypophosphatasia Started Enzyme Replacement Therapy Since Babyhood Stage

A Case of Hypophosphatasia Started Enzyme Replacement Therapy Since Babyhood Stage

Background: Hypophosphatasia (HPP) is an inherited disease caused by low activity of tissue-nonspecific alkaline phosphatase. Dental characteristics include premature loss of primary teeth, enlarged pulp chambers, and enamel hypoplasia. Although enzyme replacement therapy with asfotase alfa was appr...

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Main Authors: Tatsuya Akitomo, Noriko Niizato, Ami Kaneki, Masashi Ogawa, Taku Nishimura, Mariko Kametani, Momoko Usuda, Yuko Iwamoto, Chieko Mitsuhata, Ryota Nomura
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Children
Subjects:
hypophosphatasia
enzyme replacement therapy
tooth exfoliation
Online Access:https://www.mdpi.com/2227-9067/12/1/61
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