iPSC-derived human sensory neurons reveal a subset of TRPV1 antagonists as anti-pruritic compounds

iPSC-derived human sensory neurons reveal a subset of TRPV1 antagonists as anti-pruritic compounds

Abstract Signaling interplay between the histamine 1 receptor (H1R) and transient receptor potential cation channel subfamily V member 1 (TRPV1) in mediating histaminergic itch has been well-established in mammalian models, but whether this is conserved in humans remains to be confirmed due to the d...

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Bibliographic Details
Main Authors: Shermaine Huiping Tay, Jeremy Kah Sheng Pang, Winanto Ng, Chong Yi Ng, Zi Jian Khong, Zheng-Shan Chong, Boon Seng Soh, Shi-Yan Ng
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Sensory neurons
Human pluripotent stem cells
MEA
Itch
Histamine receptor
TRPV1
Online Access:https://doi.org/10.1038/s41598-024-82549-7
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https://doi.org/10.1038/s41598-024-82549-7

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