Subinhibitory concentrations of meropenem stimulate membrane vesicle production and modulate immune response in Bacteroides fragilis infection

Subinhibitory concentrations of meropenem stimulate membrane vesicle production and modulate immune response in Bacteroides fragilis infection

This study explores an adaptation mechanism of Bacteroides fragilis to subinhibitory concentrations of meropenem, characterized by an alteration in the production of membrane vesicles (MVs) and modulation of the host inflammatory response. Using a rat model of infection, we demonstrated a significan...

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Bibliographic Details
Main Authors: Saniya Kozhakhmetova, Ayazhan Bekbayeva, Elena Zholdybayeva, Tatyana Krivoruchko, Natalya Dashevskaya, Zhanel Mukhanbetzhanova, Elizaveta Vinogradova, Almagul Kushugulova, Samat Kozhakhmetov
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Current Research in Microbial Sciences
Subjects:
Bacteroides fragilis
Subinhibitory concentrations
Meropenem
Мembrane vesicles
Inflammatory response
Cytokine modulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2666517424000774
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