Anti-cancer drug sensitivity testing and preclinical evaluation of the anti-cancer potential of WEE1 inhibitor in triple-negative breast cancer patient-derived organoids and xenograft models

Anti-cancer drug sensitivity testing and preclinical evaluation of the anti-cancer potential of WEE1 inhibitor in triple-negative breast cancer patient-derived organoids and xenograft models

Abstract Background Relevant surrogates that maintain the pathological and physiological properties of patient tumors are essential for guiding triple-negative breast cancer (TNBC) therapy. The goals are to generate patient-derived organoids (PDOs), xenografts (PDXs), and PDX-derived organoids (PDXO...

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Main Authors: Seungyeon Ryu, Hoe Suk Kim, Sangeun Lee, So-Hyun Yoon, Moonjou Baek, A Young Park, Han-Byoel Lee, Ga Yeon Kim, Kyung Hyeun Park, Ji-Jung Jung, Yireh Han, Dong Woo Lee, Bosung Ku, Wonshik Han
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Breast Cancer Research
Subjects:
Patient-derived organoid (PDO)
Patient-derived xenograft (PDX)
PDX-derived organoid (PDXO)
High-throughput screening (HTS)
WEE1
AZD1775
Online Access:https://doi.org/10.1186/s13058-025-02063-0
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https://doi.org/10.1186/s13058-025-02063-0

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