Angiotensin type-1 receptor autoantibodies promote alpha-synuclein aggregation in dopaminergic neurons

Angiotensin type-1 receptor autoantibodies promote alpha-synuclein aggregation in dopaminergic neurons

Angiotensin, through its type-1 receptor (AT1), is a major inducer of inflammation and oxidative stress, contributing to several diseases. Autoimmune processes have been involved in neurodegeneration, including Parkinson’s disease (PD). AT1 autoantibodies (AT1-AA) enhance neurodegeneration and PD, w...

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Bibliographic Details
Main Authors: Lucia Lage, Ana I. Rodríguez-Perez, Jose L. Labandeira-Garcia, Antonio Dominguez-Meijide
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
alpha-synuclein
angiotensin
autoimmunity
neurodegeneration
Parkinson
protein aggregates
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1457459/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1457459/full

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