HDL from 36-h fasted participants potently promotes efflux of cholesteryl ester from activated microglia

HDL from 36-h fasted participants potently promotes efflux of cholesteryl ester from activated microglia

The potential impact of lifestyle changes such as prolonged fasting on brain health still remains unclear. Neurodegenerative diseases often exhibit two key hallmarks: accumulation of misfolded proteins such as amyloid beta oligomers (AβO) and intracellular cholesterol accumulation. In this study, we...

Full description

Saved in:
Bibliographic Details
Main Authors: Joanne K. Agus, Oscar M. Muñoz Herrera, Christopher H. Rhodes, Jack Jingyuan Zheng, Chenghao Zhu, Maurice Wong, Xinyu Tang, Izumi Maezawa, Lee-Way Jin, Carlito B. Lebrilla, Danielle J. Harvey, Angela M. Zivkovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
high-density lipoprotein
dementia
Alzheimer’s disease
fasting
cholesterol accumulation
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1629496/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2025.1629496/full

Similar Items