A Simple HPLC-DAD Method for the Therapeutic Monitoring of Clozapine and Related Metabolites in Human Plasma and Urine Samples

A Simple HPLC-DAD Method for the Therapeutic Monitoring of Clozapine and Related Metabolites in Human Plasma and Urine Samples

Clozapine and its metabolites require close therapeutic monitoring (TDM) in patients due to poor correlation between the administrated doses and resulting plasma concentrations, the narrow therapeutic interval, high inter-individual variability, and the risk of serious side effects once toxic levels...

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Bibliographic Details
Main Authors: Mircea-Alexandru Comănescu, Dana-Maria Preda, Dalia-Simona Miron, Flavian-Ștefan Rădulescu, Victor Voicu, Andrei-Valentin Medvedovici
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Molecules
Subjects:
clozapine
metabolites
HPLC-DAD
LLE
<i>n</i>-octanol
SUPRAS
Online Access:https://www.mdpi.com/1420-3049/29/21/5039
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