A proteomic network approach across the ALS‐FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain

A proteomic network approach across the ALS‐FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain

Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases with overlap in clinical presentation, neuropathology, and genetic underpinnings. The molecular basis for the overlap of these disorders is not well established. We performed a comparative u...

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Bibliographic Details
Main Authors: Mfon E Umoh, Eric B Dammer, Jingting Dai, Duc M Duong, James J Lah, Allan I Levey, Marla Gearing, Jonathan D Glass, Nicholas T Seyfried
Format: Article
Language:English
Published: Springer Nature 2017-11-01
Series:EMBO Molecular Medicine
Subjects:
C9orf72 expansion mutation
mass spectrometry
neurodegeneration
protein co‐expression
TDP‐43
Online Access:https://doi.org/10.15252/emmm.201708202
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https://doi.org/10.15252/emmm.201708202

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