Generating and monitoring mild hyperthermia using a ring array ultrasound transducer
Objective To demonstrate the feasibility of using a ring array ultrasound (US) transducer, guided by ultrasound tomography (UST), for generating and monitoring mild hyperthermia (MHTh).Methods In silico and in vitro experiments were designed to evaluate the efficacy of a ring array US transducer for...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2376681 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841560917730394112 |
|---|---|
| author | David Bustamante Yan Yan Trevor Mitcham Rehman Ali Brian Marples Kimberly R. Gergelis Peter Littrup Nebojsa Duric Mohammad Mehrmohammadi |
| author_facet | David Bustamante Yan Yan Trevor Mitcham Rehman Ali Brian Marples Kimberly R. Gergelis Peter Littrup Nebojsa Duric Mohammad Mehrmohammadi |
| author_sort | David Bustamante |
| collection | DOAJ |
| description | Objective To demonstrate the feasibility of using a ring array ultrasound (US) transducer, guided by ultrasound tomography (UST), for generating and monitoring mild hyperthermia (MHTh).Methods In silico and in vitro experiments were designed to evaluate the efficacy of a ring array US transducer for generating MHTh and monitoring changes in temperature. In a series of in silico studies, we compared the acoustic focal profiles produced by a ring array US transducer transmitting at different frequencies and further investigated the effectiveness of UST-guidance in implementing aberration correction to enhance the focal profile. In vitro experiments evaluated the capability of using a ring array US transducer to generate and maintain MHTh and the accuracy of using UST to monitor temperature changes.Results The simulations demonstrated that a ring array US transducer achieves symmetrical and localized acoustic focusing. In a heterogenous tissue model, a ring array US transducer achieved a superior acoustic focus by implementing aberration correction with guidance from UST. In vitro experiments demonstrated the capability of a ring array US transducer to generate MHTh in a tissue-mimicking phantom in an average of 117 ± 18 s and subsequently maintain MHTh. Lastly, a ring array US transducer utilized UST to track temperature changes in a preheated water-filled inclusion while it passively cooled from 45 °C to 25 °C, with a maximum error of 0.58 °C.Conclusion A ring array US transducer can noninvasively generate and monitor MHTh, overcoming many limitations of current clinical systems. The closed geometry of the transducer is optimal for acoustic focusing and UST-guidance allows for improved aberration correction in a heterogenous medium. Utilizing UST thermometry with the same ring array US transducer will allow for implementing an image-guided, temperature-controlled, all-acoustic MHTh system. |
| format | Article |
| id | doaj-art-b8af422259b94bebbe7684b754813321 |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-b8af422259b94bebbe7684b7548133212025-01-03T09:30:28ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2376681Generating and monitoring mild hyperthermia using a ring array ultrasound transducerDavid Bustamante0Yan Yan1Trevor Mitcham2Rehman Ali3Brian Marples4Kimberly R. Gergelis5Peter Littrup6Nebojsa Duric7Mohammad Mehrmohammadi8Department of Biomedical Engineering, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York, USADepartment of Imaging Sciences, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York, USADepartment of Imaging Sciences, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York, USADepartment of Imaging Sciences, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York, USADepartment of Radiation Oncology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York, USADepartment of Radiation Oncology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York, USADepartment of Biomedical Engineering, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York, USADepartment of Biomedical Engineering, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York, USADepartment of Biomedical Engineering, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York, USAObjective To demonstrate the feasibility of using a ring array ultrasound (US) transducer, guided by ultrasound tomography (UST), for generating and monitoring mild hyperthermia (MHTh).Methods In silico and in vitro experiments were designed to evaluate the efficacy of a ring array US transducer for generating MHTh and monitoring changes in temperature. In a series of in silico studies, we compared the acoustic focal profiles produced by a ring array US transducer transmitting at different frequencies and further investigated the effectiveness of UST-guidance in implementing aberration correction to enhance the focal profile. In vitro experiments evaluated the capability of using a ring array US transducer to generate and maintain MHTh and the accuracy of using UST to monitor temperature changes.Results The simulations demonstrated that a ring array US transducer achieves symmetrical and localized acoustic focusing. In a heterogenous tissue model, a ring array US transducer achieved a superior acoustic focus by implementing aberration correction with guidance from UST. In vitro experiments demonstrated the capability of a ring array US transducer to generate MHTh in a tissue-mimicking phantom in an average of 117 ± 18 s and subsequently maintain MHTh. Lastly, a ring array US transducer utilized UST to track temperature changes in a preheated water-filled inclusion while it passively cooled from 45 °C to 25 °C, with a maximum error of 0.58 °C.Conclusion A ring array US transducer can noninvasively generate and monitor MHTh, overcoming many limitations of current clinical systems. The closed geometry of the transducer is optimal for acoustic focusing and UST-guidance allows for improved aberration correction in a heterogenous medium. Utilizing UST thermometry with the same ring array US transducer will allow for implementing an image-guided, temperature-controlled, all-acoustic MHTh system.https://www.tandfonline.com/doi/10.1080/02656736.2024.2376681Ultrasoundtomographyimage-guidedmild hyperthermiaring array transducer |
| spellingShingle | David Bustamante Yan Yan Trevor Mitcham Rehman Ali Brian Marples Kimberly R. Gergelis Peter Littrup Nebojsa Duric Mohammad Mehrmohammadi Generating and monitoring mild hyperthermia using a ring array ultrasound transducer International Journal of Hyperthermia Ultrasound tomography image-guided mild hyperthermia ring array transducer |
| title | Generating and monitoring mild hyperthermia using a ring array ultrasound transducer |
| title_full | Generating and monitoring mild hyperthermia using a ring array ultrasound transducer |
| title_fullStr | Generating and monitoring mild hyperthermia using a ring array ultrasound transducer |
| title_full_unstemmed | Generating and monitoring mild hyperthermia using a ring array ultrasound transducer |
| title_short | Generating and monitoring mild hyperthermia using a ring array ultrasound transducer |
| title_sort | generating and monitoring mild hyperthermia using a ring array ultrasound transducer |
| topic | Ultrasound tomography image-guided mild hyperthermia ring array transducer |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2376681 |
| work_keys_str_mv | AT davidbustamante generatingandmonitoringmildhyperthermiausingaringarrayultrasoundtransducer AT yanyan generatingandmonitoringmildhyperthermiausingaringarrayultrasoundtransducer AT trevormitcham generatingandmonitoringmildhyperthermiausingaringarrayultrasoundtransducer AT rehmanali generatingandmonitoringmildhyperthermiausingaringarrayultrasoundtransducer AT brianmarples generatingandmonitoringmildhyperthermiausingaringarrayultrasoundtransducer AT kimberlyrgergelis generatingandmonitoringmildhyperthermiausingaringarrayultrasoundtransducer AT peterlittrup generatingandmonitoringmildhyperthermiausingaringarrayultrasoundtransducer AT nebojsaduric generatingandmonitoringmildhyperthermiausingaringarrayultrasoundtransducer AT mohammadmehrmohammadi generatingandmonitoringmildhyperthermiausingaringarrayultrasoundtransducer |