Impact of antisperm antibodies on sperm functions and fertility in livestock: A narrative review
Spermatozoa are recognized as foreign cells by both male and female immune systems, leading to the production of antisperm antibodies (ASAs) when sperm are exposed to immune system due to a breach in the mucosal barrier. ASAs can be found in both sexes, though concentrations vary by individual and s...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
|
| Series: | Asian Pacific Journal of Reproduction |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/apjr.apjr_175_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841556967265402880 |
|---|---|
| author | Channareddi Kuntareddi Kamaraj Elango Pradeep Nag Arumugam Kumaresan |
| author_facet | Channareddi Kuntareddi Kamaraj Elango Pradeep Nag Arumugam Kumaresan |
| author_sort | Channareddi Kuntareddi |
| collection | DOAJ |
| description | Spermatozoa are recognized as foreign cells by both male and female immune systems, leading to the production of antisperm antibodies (ASAs) when sperm are exposed to immune system due to a breach in the mucosal barrier. ASAs can be found in both sexes, though concentrations vary by individual and sex. This review examines ASAs production, their specific binding locations on sperm, and how ASAs may impair key sperm functions, including motility, viability, acrosome reaction, and capacitation. While ASAs are known to potentially interfere with sperm quality and sperm binding to zona pellucida in both humans and livestock, their impact on fertility remains debated, as ASAs are also detected in a significant number of fertile individuals. Furthermore, the practical relevance of ASAs screening in fertility assessment lacks consensus, with some findings suggesting that ASAs might even aid fertilization under certain conditions. By compiling the information on ASAs and their effects on semen quality and fertility, this review aims to provide a comprehensive understanding of the role of ASAs in infertility. |
| format | Article |
| id | doaj-art-b88080ce981944478253743fdbf90205 |
| institution | Kabale University |
| issn | 2305-0500 2305-0519 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Reproduction |
| spelling | doaj-art-b88080ce981944478253743fdbf902052025-01-07T04:52:33ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Reproduction2305-05002305-05192024-12-0113625126010.4103/apjr.apjr_175_24Impact of antisperm antibodies on sperm functions and fertility in livestock: A narrative reviewChannareddi KuntareddiKamaraj ElangoPradeep NagArumugam KumaresanSpermatozoa are recognized as foreign cells by both male and female immune systems, leading to the production of antisperm antibodies (ASAs) when sperm are exposed to immune system due to a breach in the mucosal barrier. ASAs can be found in both sexes, though concentrations vary by individual and sex. This review examines ASAs production, their specific binding locations on sperm, and how ASAs may impair key sperm functions, including motility, viability, acrosome reaction, and capacitation. While ASAs are known to potentially interfere with sperm quality and sperm binding to zona pellucida in both humans and livestock, their impact on fertility remains debated, as ASAs are also detected in a significant number of fertile individuals. Furthermore, the practical relevance of ASAs screening in fertility assessment lacks consensus, with some findings suggesting that ASAs might even aid fertilization under certain conditions. By compiling the information on ASAs and their effects on semen quality and fertility, this review aims to provide a comprehensive understanding of the role of ASAs in infertility.https://journals.lww.com/10.4103/apjr.apjr_175_24subfertilityantigensperm qualitymale fertilityimmunological infertilityfertilization |
| spellingShingle | Channareddi Kuntareddi Kamaraj Elango Pradeep Nag Arumugam Kumaresan Impact of antisperm antibodies on sperm functions and fertility in livestock: A narrative review Asian Pacific Journal of Reproduction subfertility antigen sperm quality male fertility immunological infertility fertilization |
| title | Impact of antisperm antibodies on sperm functions and fertility in livestock: A narrative review |
| title_full | Impact of antisperm antibodies on sperm functions and fertility in livestock: A narrative review |
| title_fullStr | Impact of antisperm antibodies on sperm functions and fertility in livestock: A narrative review |
| title_full_unstemmed | Impact of antisperm antibodies on sperm functions and fertility in livestock: A narrative review |
| title_short | Impact of antisperm antibodies on sperm functions and fertility in livestock: A narrative review |
| title_sort | impact of antisperm antibodies on sperm functions and fertility in livestock a narrative review |
| topic | subfertility antigen sperm quality male fertility immunological infertility fertilization |
| url | https://journals.lww.com/10.4103/apjr.apjr_175_24 |
| work_keys_str_mv | AT channareddikuntareddi impactofantispermantibodiesonspermfunctionsandfertilityinlivestockanarrativereview AT kamarajelango impactofantispermantibodiesonspermfunctionsandfertilityinlivestockanarrativereview AT pradeepnag impactofantispermantibodiesonspermfunctionsandfertilityinlivestockanarrativereview AT arumugamkumaresan impactofantispermantibodiesonspermfunctionsandfertilityinlivestockanarrativereview |