H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis.

H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis.

Two classes of antiviral drugs, neuraminidase inhibitors and adamantanes, are approved for prophylaxis and therapy against influenza virus infections. A major concern is that antiviral resistant viruses emerge and spread in the human population. The 2009 pandemic H1N1 virus is already resistant to a...

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Main Authors: Erhard van der Vries, Patrick J Collins, Sebastien G Vachieri, Xiaoli Xiong, Junfeng Liu, Philip A Walker, Lesley F Haire, Alan J Hay, Martin Schutten, Albert D M E Osterhaus, Steve R Martin, Charles A B Boucher, John J Skehel, Steve J Gamblin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-09-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002914&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002914&type=printable

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