The identification Mycobacterium tuberculosis genes that modulate long term survival in the presence of rifampicin and streptomycin

The identification Mycobacterium tuberculosis genes that modulate long term survival in the presence of rifampicin and streptomycin

Abstract In 2023, Mycobacterium tuberculosis (Mtb) caused 10.6 million new tuberculosis cases and 1.3 million deaths. The WHO proscribed treatment is not always successful, even when strains were sensitive to the antibiotics.as clinical Mtb populations contain phenotypically tolerant subpopulations,...

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Bibliographic Details
Main Authors: Johana E. Hernández Toloza, Ye Xu, Tom A. Mendum, Bianca Sica Siedler, Rosalyn Casey, Huihai Wu, Kerstin Williams, Suzanne Hingley-Wilson, Johnjoe McFadden
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Mycobacterium tuberculosis
Transposon library
Tolerance
Persister
Cell wall
Methylcitrate cycle
Online Access:https://doi.org/10.1038/s41598-025-04038-9
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https://doi.org/10.1038/s41598-025-04038-9

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