Dimethyl sulfoxide in cryopreserved mesenchymal stromal cell therapy products: is there a safety risk to patients?

Abstract Dimethyl sulfoxide (DMSO) is the preferred cryoprotectant for the cryopreservation of mesenchymal stromal cells (MSCs). As DMSO has been associated with in-vivo toxicity, its potential side effects when administered with MSC therapies are a matter of debate. To contribute to the assessment...

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Bibliographic Details
Main Authors: Elke Niebergall-Roth, Mark Andreas Kluth
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Online Access:https://doi.org/10.1186/s12967-025-06807-6
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