Dual effects of indoxyl sulfate on modulation of human hepatic CYP3A activity, with individual differences.

Dual effects of indoxyl sulfate on modulation of human hepatic CYP3A activity, with individual differences.

This study aimed to identify gut microbiota-derived metabolites governing the activity of hepatic CYP3A in blood level. Indole propionic acid (IPA) and lithocholic acid, ligands of the pregnane X receptor, a transcriptional regulator of CYP3A, and various gut microbiota-derived metabolites in blood...

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Bibliographic Details
Main Authors: Masao Togao, Naoyuki Asakawa, Gaku Wagai, Yuki Ohta-Takada, Jun Otsuka, Minoru Ando, Akinobu Kurita, Koji Kawakami
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0328182
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