Potential link between transfusion-transmitted infections and ABO and Rh blood group systems in healthy blood donors
Background: Screening blood donations is essential to prevent transfusion-transmitted infections (TTIs). Research indicates that ABO and Rh blood groups might influence infection transmission risks. Materials and Methods: This retrospective study examined data from 10,470 healthy blood donors over s...
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | MGM Journal of Medical Sciences |
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| Online Access: | https://doi.org/10.4103/mgmj.mgmj_252_24 |
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| author | Aneesha Kataria Durre Aden Sabina Khan Meesa Mehraj Yasir Alvi Sujata Jetley |
| author_facet | Aneesha Kataria Durre Aden Sabina Khan Meesa Mehraj Yasir Alvi Sujata Jetley |
| author_sort | Aneesha Kataria |
| collection | DOAJ |
| description | Background: Screening blood donations is essential to prevent transfusion-transmitted infections (TTIs). Research indicates that ABO and Rh blood groups might influence infection transmission risks. Materials and Methods: This retrospective study examined data from 10,470 healthy blood donors over seven years (2016–2022) at a tertiary care hospital. Blood typing was performed for ABO and Rh groups, and all voluntary and replacement donors were screened for TTI markers—hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), malaria, and syphilis—using third-generation ELISA kits, rapid tests, rapid plasma reagin (RPR), and venereal disease research laboratory (VDRL). Statistical analyzes were conducted using Chi-square and Fisher’s exact test in Statistical Package for Social Sciences version 26.0. Results: Among the 10,470 male donors screened, 173 were replacement donors, and 6 were voluntary donors. TTI positivity was identified in 1.79% of donors, with the following breakdown: 69.27% positive for hepatitis B, 15.6% for hepatitis C, 11.7% for HIV, and 5% for syphilis. The highest TTI prevalence was observed in the B blood group (43%), followed by O (30.16%), A (21.78%), and AB (6.7%). Overall, Rh-positive individuals were more susceptible, and a significant association was observed between Rh-negative donors and HBV infection. Conclusion: The B-positive blood group showed the highest seroprevalence for TTIs. However, no statistically significant association was found between TTI prevalence and ABO or Rh blood group systems. |
| format | Article |
| id | doaj-art-b76cf1f3e6384064aea37037718f581c |
| institution | Kabale University |
| issn | 2347-7946 2347-7962 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | MGM Journal of Medical Sciences |
| spelling | doaj-art-b76cf1f3e6384064aea37037718f581c2025-01-17T10:55:33ZengWolters Kluwer Medknow PublicationsMGM Journal of Medical Sciences2347-79462347-79622024-12-0111468468910.4103/mgmj.mgmj_252_24Potential link between transfusion-transmitted infections and ABO and Rh blood group systems in healthy blood donorsAneesha KatariaDurre AdenSabina KhanMeesa MehrajYasir AlviSujata JetleyBackground: Screening blood donations is essential to prevent transfusion-transmitted infections (TTIs). Research indicates that ABO and Rh blood groups might influence infection transmission risks. Materials and Methods: This retrospective study examined data from 10,470 healthy blood donors over seven years (2016–2022) at a tertiary care hospital. Blood typing was performed for ABO and Rh groups, and all voluntary and replacement donors were screened for TTI markers—hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), malaria, and syphilis—using third-generation ELISA kits, rapid tests, rapid plasma reagin (RPR), and venereal disease research laboratory (VDRL). Statistical analyzes were conducted using Chi-square and Fisher’s exact test in Statistical Package for Social Sciences version 26.0. Results: Among the 10,470 male donors screened, 173 were replacement donors, and 6 were voluntary donors. TTI positivity was identified in 1.79% of donors, with the following breakdown: 69.27% positive for hepatitis B, 15.6% for hepatitis C, 11.7% for HIV, and 5% for syphilis. The highest TTI prevalence was observed in the B blood group (43%), followed by O (30.16%), A (21.78%), and AB (6.7%). Overall, Rh-positive individuals were more susceptible, and a significant association was observed between Rh-negative donors and HBV infection. Conclusion: The B-positive blood group showed the highest seroprevalence for TTIs. However, no statistically significant association was found between TTI prevalence and ABO or Rh blood group systems.https://doi.org/10.4103/mgmj.mgmj_252_24abo and rh blood groupsblood donorstransfusion-transmitted infections |
| spellingShingle | Aneesha Kataria Durre Aden Sabina Khan Meesa Mehraj Yasir Alvi Sujata Jetley Potential link between transfusion-transmitted infections and ABO and Rh blood group systems in healthy blood donors MGM Journal of Medical Sciences abo and rh blood groups blood donors transfusion-transmitted infections |
| title | Potential link between transfusion-transmitted infections and ABO and Rh blood group systems in healthy blood donors |
| title_full | Potential link between transfusion-transmitted infections and ABO and Rh blood group systems in healthy blood donors |
| title_fullStr | Potential link between transfusion-transmitted infections and ABO and Rh blood group systems in healthy blood donors |
| title_full_unstemmed | Potential link between transfusion-transmitted infections and ABO and Rh blood group systems in healthy blood donors |
| title_short | Potential link between transfusion-transmitted infections and ABO and Rh blood group systems in healthy blood donors |
| title_sort | potential link between transfusion transmitted infections and abo and rh blood group systems in healthy blood donors |
| topic | abo and rh blood groups blood donors transfusion-transmitted infections |
| url | https://doi.org/10.4103/mgmj.mgmj_252_24 |
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