Pathogenic single nucleotide polymorphisms in RhoA gene: Insights into structural and functional impacts on RhoA-PLD1 interaction through molecular dynamics simulation

Pathogenic single nucleotide polymorphisms in RhoA gene: Insights into structural and functional impacts on RhoA-PLD1 interaction through molecular dynamics simulation

Molecular switches serve as key regulators of biological systems by acting as one of the crucial driving forces in the initiation of signal transduction pathway cascades. The Ras homolog gene family member A (RhoA) is one of the molecular switches that binds with GTP in order to cycle between an act...

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Bibliographic Details
Main Authors: Mahbub Hasan, Md. Nayem Sarker, Tazkia Jabin, Saifuddin Sarker, Shamim Ahmed, Mohammad Abdullah-Al-Shoeb, Tanvir Hossain
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Current Research in Structural Biology
Subjects:
RhoA
Molecular switching
Deleterious SNP
Molecular dynamic simulation
RhoA-GDP-PLD1
Online Access:http://www.sciencedirect.com/science/article/pii/S2665928X24000369
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