The Significance of MAPK Signaling Pathway in the Diagnosis and Subtype Classification of Intervertebral Disc Degeneration

The Significance of MAPK Signaling Pathway in the Diagnosis and Subtype Classification of Intervertebral Disc Degeneration

ABSTRACT Background Intervertebral disc degeneration (IDD) is a human aging disease related mainly to inflammation, cellular senescence, RNA/DNA methylation, and ECM. The mitogen‐activated protein kinase (MAPK) signaling pathway is engaged in multiple biological functions by phosphorylating specific...

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Main Authors: Yong Liu, Xueyan Chen, Jingwen Chen, Chao Song, Zhangchao Wei, Zongchao Liu, Fei Liu
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:JOR Spine
Subjects:
consensus clustering
immune cell infiltration
intervertebral disc degeneration
MAPK signaling pathway
Online Access:https://doi.org/10.1002/jsp2.70060
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https://doi.org/10.1002/jsp2.70060

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