Could <i>SLC26A7</i> Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma?
Background/Objectives: A modern classification distinguishes between two nosological entities posing an intermediate risk between differentiated and anaplastic carcinoma: poorly differentiated thyroid carcinoma and differentiated high-grade thyroid carcinoma. There are currently few studies searchin...
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2024-11-01
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| author | Sergei E. Titov Evgeniya S. Kozorezova Sergei A. Lukyanov Sergei V. Sergiyko Pavel S. Demenkov Yulia A. Veryaskina Sergey L. Vorobyev Ilya V. Sleptsov Roman A. Chernikov Natalia I. Timofeeva Svetlana V. Barashkova Elena L. Lushnikova Anna A. Uspenskaya Anna V. Zolotoukho Olga V. Romanova Igor F. Zhimulev |
| author_facet | Sergei E. Titov Evgeniya S. Kozorezova Sergei A. Lukyanov Sergei V. Sergiyko Pavel S. Demenkov Yulia A. Veryaskina Sergey L. Vorobyev Ilya V. Sleptsov Roman A. Chernikov Natalia I. Timofeeva Svetlana V. Barashkova Elena L. Lushnikova Anna A. Uspenskaya Anna V. Zolotoukho Olga V. Romanova Igor F. Zhimulev |
| author_sort | Sergei E. Titov |
| collection | DOAJ |
| description | Background/Objectives: A modern classification distinguishes between two nosological entities posing an intermediate risk between differentiated and anaplastic carcinoma: poorly differentiated thyroid carcinoma and differentiated high-grade thyroid carcinoma. There are currently few studies searching for the preoperative molecular genetic markers of high-grade papillary thyroid carcinoma (PTC HG), primarily because of a recent WHO reclassification and singling out of a separate entity: high-grade follicular cell-derived nonanaplastic thyroid carcinoma. Therefore, this work was aimed at identifying PTC HG-specific microRNAs and mRNAs that reliably distinguish them from differentiated papillary thyroid carcinoma in preoperative cytology specimens (fine-needle aspiration biopsies). Methods: A molecular genetic profile (expression levels of 14 genes and eight microRNAs) was studied in 110 cytology specimens from patients with PTC: 13 PTCs HG and 97 PTCs without features of HG. Results: Of the examined eight microRNAs and 14 genes, significant differences in the expression levels between the PTC and PTC HG groups were revealed for genes <i>SLC26A7</i>, <i>TFF3</i>, and <i>TPO</i>. Only one gene (<i>SLC26A7</i>) proved to be crucial for detecting PTC HG. It showed the largest area under the ROC curve (0.816) in differentiation between the PTC and PTC HG groups and was the key element of the decision tree by ensuring 54% sensitivity and 87.6% specificity. Conclusions: Early preoperative diagnosis of PTC HG in patients with early stages of this cancer type will allow clinicians to modify a treatment strategy toward a larger surgery volume and lymph node dissection and may provide indications for subsequent radioactive iodine therapy. |
| format | Article |
| id | doaj-art-b73a06249d2b48e2a9a59a9b5895a5da |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-b73a06249d2b48e2a9a59a9b5895a5da2024-12-13T16:24:32ZengMDPI AGDiagnostics2075-44182024-11-011423265210.3390/diagnostics14232652Could <i>SLC26A7</i> Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma?Sergei E. Titov0Evgeniya S. Kozorezova1Sergei A. Lukyanov2Sergei V. Sergiyko3Pavel S. Demenkov4Yulia A. Veryaskina5Sergey L. Vorobyev6Ilya V. Sleptsov7Roman A. Chernikov8Natalia I. Timofeeva9Svetlana V. Barashkova10Elena L. Lushnikova11Anna A. Uspenskaya12Anna V. Zolotoukho13Olga V. Romanova14Igor F. Zhimulev15Department of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, RussiaNational Center of Clinical Morphological Diagnostics, Saint Petersburg 192283, RussiaDepartment of General and Pediatric Surgery, South Ural State Medical University, Chelyabinsk 454092, RussiaDepartment of General and Pediatric Surgery, South Ural State Medical University, Chelyabinsk 454092, RussiaDepartment of Natural Sciences, Novosibirsk State University, Novosibirsk 630090, RussiaDepartment of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, RussiaNational Center of Clinical Morphological Diagnostics, Saint Petersburg 192283, RussiaDepartment of Endocrine Surgery, Saint Petersburg State University Hospital, Saint Petersburg 199034, RussiaDepartment of Endocrine Surgery, Saint Petersburg State University Hospital, Saint Petersburg 199034, RussiaDepartment of Endocrine Surgery, Saint Petersburg State University Hospital, Saint Petersburg 199034, RussiaNational Center of Clinical Morphological Diagnostics, Saint Petersburg 192283, RussiaDepartment of Molecular Pathology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk 630117, RussiaDepartment of Endocrine Surgery, Saint Petersburg State University Hospital, Saint Petersburg 199034, RussiaDepartment of Endocrine Surgery, Saint Petersburg State University Hospital, Saint Petersburg 199034, RussiaN.N. Blokhin National Medical Research Center of Oncology, Moscow 115478, RussiaDepartment of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, RussiaBackground/Objectives: A modern classification distinguishes between two nosological entities posing an intermediate risk between differentiated and anaplastic carcinoma: poorly differentiated thyroid carcinoma and differentiated high-grade thyroid carcinoma. There are currently few studies searching for the preoperative molecular genetic markers of high-grade papillary thyroid carcinoma (PTC HG), primarily because of a recent WHO reclassification and singling out of a separate entity: high-grade follicular cell-derived nonanaplastic thyroid carcinoma. Therefore, this work was aimed at identifying PTC HG-specific microRNAs and mRNAs that reliably distinguish them from differentiated papillary thyroid carcinoma in preoperative cytology specimens (fine-needle aspiration biopsies). Methods: A molecular genetic profile (expression levels of 14 genes and eight microRNAs) was studied in 110 cytology specimens from patients with PTC: 13 PTCs HG and 97 PTCs without features of HG. Results: Of the examined eight microRNAs and 14 genes, significant differences in the expression levels between the PTC and PTC HG groups were revealed for genes <i>SLC26A7</i>, <i>TFF3</i>, and <i>TPO</i>. Only one gene (<i>SLC26A7</i>) proved to be crucial for detecting PTC HG. It showed the largest area under the ROC curve (0.816) in differentiation between the PTC and PTC HG groups and was the key element of the decision tree by ensuring 54% sensitivity and 87.6% specificity. Conclusions: Early preoperative diagnosis of PTC HG in patients with early stages of this cancer type will allow clinicians to modify a treatment strategy toward a larger surgery volume and lymph node dissection and may provide indications for subsequent radioactive iodine therapy.https://www.mdpi.com/2075-4418/14/23/2652papillary thyroid carcinomahigh-grade carcinomapreoperative diagnosismolecular marker<i>SLC26A7</i> |
| spellingShingle | Sergei E. Titov Evgeniya S. Kozorezova Sergei A. Lukyanov Sergei V. Sergiyko Pavel S. Demenkov Yulia A. Veryaskina Sergey L. Vorobyev Ilya V. Sleptsov Roman A. Chernikov Natalia I. Timofeeva Svetlana V. Barashkova Elena L. Lushnikova Anna A. Uspenskaya Anna V. Zolotoukho Olga V. Romanova Igor F. Zhimulev Could <i>SLC26A7</i> Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma? Diagnostics papillary thyroid carcinoma high-grade carcinoma preoperative diagnosis molecular marker <i>SLC26A7</i> |
| title | Could <i>SLC26A7</i> Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma? |
| title_full | Could <i>SLC26A7</i> Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma? |
| title_fullStr | Could <i>SLC26A7</i> Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma? |
| title_full_unstemmed | Could <i>SLC26A7</i> Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma? |
| title_short | Could <i>SLC26A7</i> Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma? |
| title_sort | could i slc26a7 i be a promising marker for preoperative diagnosis of high grade papillary thyroid carcinoma |
| topic | papillary thyroid carcinoma high-grade carcinoma preoperative diagnosis molecular marker <i>SLC26A7</i> |
| url | https://www.mdpi.com/2075-4418/14/23/2652 |
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