Identifying CD19-targeted CAR-T cell immune pathways in an in vitro human immune mimetic cytokine release assay

Identifying CD19-targeted CAR-T cell immune pathways in an in vitro human immune mimetic cytokine release assay

CD19-targeted chimeric antigen receptor-modified T (CAR-T) cells have shown success in clinical studies, with several CD19 CAR-T cell products now having been approved for market use. However, this cell therapy can be associated with side effects such as cytokine release syndrome (CRS). Therefore, p...

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Bibliographic Details
Main Authors: Thuvan Dinh-Le, John Escobar, Louis Poisson, Karissa Adkins, Maria Jornet Culubret, Lukas Scheller, Jan van den Brulle, Michael Hudecek, Donald R. Drake III, Miriam Alb, Ernesto Luna
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Immunotoxicology
Subjects:
CAR-T cells
cytokines
3D co-culture
T cell activation
in vitro
Online Access:https://www.tandfonline.com/doi/10.1080/1547691X.2024.2378729
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https://www.tandfonline.com/doi/10.1080/1547691X.2024.2378729

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