SIRPA, BTN3A1, and TDO2 in osteosarcoma: a prognostic triad with therapeutic implications from integrated genomic and pharmacogenomic data

SIRPA, BTN3A1, and TDO2 in osteosarcoma: a prognostic triad with therapeutic implications from integrated genomic and pharmacogenomic data

Abstract The limited understanding of the prognostic implications of immune checkpoint molecules in osteosarcoma (OS) poses significant challenges for improving patient outcomes. There is a gap in the identification of reliable biomarkers that can predict treatment response and prognosis in OS patie...

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Bibliographic Details
Main Authors: Han-jing Zhang, Zhi-Jun Yang, Wen Huang, Dan Chen, Jie Xiang, Wen-kang Chen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Osteosarcoma
Immune checkpoints
Prognosis
Immune therapy
SIRPA
Online Access:https://doi.org/10.1186/s13018-025-06171-7
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https://doi.org/10.1186/s13018-025-06171-7

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