Enhanced cancer immunotherapy via synergistic action of NO-Donor nanoparticles (NanoARG) and PD-1 antibody

Enhanced cancer immunotherapy via synergistic action of NO-Donor nanoparticles (NanoARG) and PD-1 antibody

This study explores the synergistic potential of PEG-b-P(L-Arg)-based polyion complex micelles (NanoARGs) combined with an immune checkpoint inhibitor (PD-1 antibody) for cancer immunotherapy. Comprehensive experiments, including micelle preparation, in vivo anti-tumor activity evaluation, nitric ox...

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Bibliographic Details
Main Authors: Ting Mei, Xin Zhang, Xiaolu Hou, Yukio Nagasaki
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Science and Technology of Advanced Materials
Subjects:
Tumor-associated macrophages
nanoparticle-based nitric oxide donor
immune checkpoint inhibitor (PD-1 antibody)
cancer immunotherapy
synergistic anti-tumor effect
poly(L-arginine)-based polymer micelles
Online Access:https://www.tandfonline.com/doi/10.1080/14686996.2025.2538430
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https://www.tandfonline.com/doi/10.1080/14686996.2025.2538430

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