Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia

Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia

Abstract Background Antipsychotic-induced movement disorders (AIMDs) are prevalent side effects of antipsychotics, particularly during the acute phase of treatment. This study aimed to elucidate the genetic mechanisms underlying AIMDs using a genome-wide association study (GWAS). Methods GWASs on AI...

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Bibliographic Details
Main Authors: Zhe Lu, Yao-Yao Sun, Zhe-Wei Kang, Guo-Rui Zhao, Yu-Yanan Zhang, Jun-Yuan Sun, Rui Yuan, Wei-Hua Yue
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Military Medical Research
Subjects:
Antipsychotic
Movement disorders
Genome-wide association study (GWAS)
Substantia nigra
Multi-ancestry validation
Online Access:https://doi.org/10.1186/s40779-025-00636-w
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https://doi.org/10.1186/s40779-025-00636-w

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