Liver TET1 promotes metabolic dysfunction-associated steatotic liver disease

Liver TET1 promotes metabolic dysfunction-associated steatotic liver disease

Abstract Global hepatic DNA methylation change has been linked to human patients with metabolic dysfunction-associated steatotic liver disease (MASLD). DNA demethylation is regulated by the TET family proteins, whose enzymatic activities require 2-oxoglutarate (2-OG) and iron that both are elevated...

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Main Authors: Hongze Chen, Muhammad Azhar Nisar, Joud Mulla, Xinjian Li, Kevin Cao, Shaolei Lu, Katsuya Nagaoka, Shang Wu, Peng-Sheng Ting, Tung-Sung Tseng, Hui-Yi Lin, Xiao-Ming Yin, Wenke Feng, Zhijin Wu, Zhixiang Cheng, William Mueller, Amalia Bay, Layla Schechner, Xuewei Bai, Chiung-Kuei Huang
Format: Article
Language:English
Published: Springer Nature 2025-03-01
Series:EMBO Molecular Medicine
Subjects:
Fatty Liver
Alcoholic Liver Disease
Nonalcoholic Fatty Liver Disease
Epigenetics
5-Hydroxymethylcytosine
Online Access:https://doi.org/10.1038/s44321-025-00224-4
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https://doi.org/10.1038/s44321-025-00224-4

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