PKM2-driven metabolic reprogramming in digestive system tumors: mechanisms, therapeutic advances, and clinical challenges
Metabolic reprogramming is a central driving force in the malignant progression of digestive system tumors. It facilitates tumor proliferation, metastasis, and therapeutic resistance through aerobic glycolysis, disordered lipid metabolism, and altered amino acid metabolism. Pyruvate kinase M2 (PKM2)...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1634786/full |
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