An adaptive peptide-binding site in ubiquitin receptor hRpn13 revealed by structural studies

An adaptive peptide-binding site in ubiquitin receptor hRpn13 revealed by structural studies

Abstract A pleckstrin-like receptor for ubiquitin (Pru) domain in hRpn13 binds ubiquitin and proteasome subunit hRpn2. Here, we report a crystal structure of Pru bound to amino acids at the extreme N-terminus (ENT) of recombinant hRpn13. ENT adopts a U shape with native sequence along one side where...

Full description

Saved in:
Bibliographic Details
Main Authors: Bakar Hassan, Monika Chandravanshi, Martin Y. Ng, Hitendra Negi, Brice A. P. Wilson, Kylie J. Walters
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60843-w
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items