Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number.

Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number.

Adult human heart mitochondrial DNA (mtDNA) has recently been shown to have a complex organization with abundant dimeric molecules, branched structures and four-way junctions. In order to understand the physiological significance of the heart-specific mtDNA maintenance mode and to find conditions th...

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Bibliographic Details
Main Authors: Jaakko L O Pohjoismäki, Steffi Goffart, Robert W Taylor, Douglas M Turnbull, Anu Suomalainen, Howard T Jacobs, Pekka J Karhunen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010426&type=printable
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