An enzyme-free electrochemical biosensor for sensitive and specific detection of microRNA-21 based on target recycling amplification and non-linear hybridization chain reaction

Abstract A novel electrochemical biosensor with high amplification efficiency was explored for serum microRNA-21 (miRNA-21) detection. This biosensor consisted of the target recycling amplification (TRA) and non-linear hybridization chain reaction (NHCR). When the target miRNA-21 was presented, hair...

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Bibliographic Details
Main Authors: Jing Guo, Shou-feng Zhao, Shuang Chen, Wei-qing Song, Li-qun Li
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-06003-y
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