Overproduction and Characterization of Recombinant Soluble Trypanosoma brucei Phospholipase A2

Overproduction and Characterization of Recombinant Soluble Trypanosoma brucei Phospholipase A2

ABSTRACT Trypanosoma brucei phospholipase A2 (TbPLA2) is a validated drug target but the difficulty in expressing its soluble recombinant protein has limited its exploitation for drug and vaccine development for African and American trypanosomiases. We utilized recombinant deoxyribonucleic acid (DNA...

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Main Authors: Oluwafemi Abiodun Adepoju, Daniel Quinnell, Harshverdhan Sirohi, Emmanuel Amlabu, Abdullahi Balarabe Sallau, Abdulrazak Ibrahim, Sunday Ene‐Ojo Atawodi, Mohammed Nasiru Shuaibu, Geoffrey Chang, Emmanuel Oluwadare Balogun
Format: Article
Language:English
Published: Wiley-VCH 2025-03-01
Series:Engineering in Life Sciences
Subjects:
kinetoplastids
neglected tropical diseases
recombinant DNA technology
Trypanosoma brucei phospholipase A2
trypanosomiasis
Online Access:https://doi.org/10.1002/elsc.70005
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https://doi.org/10.1002/elsc.70005

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