Intestine-derived fibroblast growth factor 19 alleviates lipopolysaccharide-induced liver injury by regulating bile acid homeostasis and directly improving oxidative stress

Intestine-derived fibroblast growth factor 19 alleviates lipopolysaccharide-induced liver injury by regulating bile acid homeostasis and directly improving oxidative stress

Background: Cholestasis plays a critical role in sepsis-associated liver injury (SALI). Intestine-derived fibroblast growth factor 19 (FGF19) is a key regulator for bile acid homeostasis. However, the roles and underlying mechanisms of FGF19 in SALI are still unclear. Methods: We conducted a case–co...

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Bibliographic Details
Main Authors: Xiaomeng Tang, Jingjing Ning, Yilin Zhao, Shuyun Feng, Lujing Shao, Tiantian Liu, Huijie Miao, Yucai Zhang, Chunxia Wang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Journal of Intensive Medicine
Subjects:
FGF19
Bile acid
Oxidative stress
Mitochondria dysfunction
Acute liver injury
Sepsis
Online Access:http://www.sciencedirect.com/science/article/pii/S2667100X24000768
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