In silico screening and experimental validation identify riboflavin as an RNA-targeted antiviral against SARS-CoV-2

In silico screening and experimental validation identify riboflavin as an RNA-targeted antiviral against SARS-CoV-2

Abstract This study explored drug repurposing strategies against conserved RNA structures in the SARS-CoV-2 genome to address viral mutation challenges. Conserved RNA elements were computationally identified by aligning 283 SARS-CoV-2 genomes from Korean patients. RNA secondary structures were predi...

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Bibliographic Details
Main Authors: Chae-Hong Jeong, Yoo Jin Na, Tae Yong Kim, So Young Lee, Jungyeon Kim, Sangmi Ryou
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Drug repurposing
Antiretroviral
RNA secondary structure
In silico
Riboflavin
SARS-CoV-2
Online Access:https://doi.org/10.1038/s41598-025-16949-8
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https://doi.org/10.1038/s41598-025-16949-8

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