Single nucleus RNA sequencing profile analysis to reveal cell type specific common molecular drivers of Parkinson’s disease and therapeutic agents

Single nucleus RNA sequencing profile analysis to reveal cell type specific common molecular drivers of Parkinson’s disease and therapeutic agents

Abstract Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, characterized by progressive motor and cognitive decline, leading to long-term disability and significantly impacting quality of life. While PD research has traditionally focused on dopaminergic neurons in the...

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Bibliographic Details
Main Authors: Md. Al Amin Pappu, Md. Alamin, Most. Humaira Sultana, AKM Azad, Md. Rabiul Auwul, Sabkat Mahmud, Alvira Ajadee, Arnob Sarker, Salem A. Alyami, Md. Nurul Haque Mollah
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Parkinson’s disease
Disability research
Single-nucleus RNA sequencing
Differential gene expression
Drug repurposing
Protein–protein interaction network
Online Access:https://doi.org/10.1038/s41598-025-09417-w
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https://doi.org/10.1038/s41598-025-09417-w

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