Rice endosperm and bran proteins ameliorate diabetic osteoporosis in Zucker Diabetic Fatty rats
We investigated whether rice protein ameliorates the osteoporosis associated with type 2 diabetes in Zucker diabetic fatty rats. Diets containing rice endosperm protein, rice bran protein, or casein were fed for 10 weeks. The rats exhibited an early stage of diabetic nephropathy and chronic kidney d...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006509 |
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| author | Masatoshi Kubota Shogo Sugaki Erika Komori Reiko Watanabe Yuki Higuchi Yukikazu Harada Hiroyuki Hashimoto Shinobu Fujimura Motoni Kadowaki |
| author_facet | Masatoshi Kubota Shogo Sugaki Erika Komori Reiko Watanabe Yuki Higuchi Yukikazu Harada Hiroyuki Hashimoto Shinobu Fujimura Motoni Kadowaki |
| author_sort | Masatoshi Kubota |
| collection | DOAJ |
| description | We investigated whether rice protein ameliorates the osteoporosis associated with type 2 diabetes in Zucker diabetic fatty rats. Diets containing rice endosperm protein, rice bran protein, or casein were fed for 10 weeks. The rats exhibited an early stage of diabetic nephropathy and chronic kidney disease–mineral and bone disorder, and parameters reflecting mineral and bone metabolism and bone structure and strength were evaluated. Feeding casein to Zucker Diabetic Fatty rats increased their serum fibroblast growth factor 23 and parathyroid hormone concentrations, suggesting relative excess phosphorus intake, a low serum osteocalcin concentration, and a slightly elevated serum tartrate-resistant acid phosphatase-5b concentration, indicating bone catabolism. In addition, the microarchitecture and strength of the femur were impaired. However, feeding rice endosperm protein and rice bran protein improved these parameters to near normal. These results imply that feeding these rice proteins causes an amelioration of diabetic osteoporosis. |
| format | Article |
| id | doaj-art-b55a3a2e446c4ea1bf5ff9bcc36c8d08 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-b55a3a2e446c4ea1bf5ff9bcc36c8d082025-01-12T05:24:47ZengElsevierJournal of Functional Foods1756-46462025-01-01124106647Rice endosperm and bran proteins ameliorate diabetic osteoporosis in Zucker Diabetic Fatty ratsMasatoshi Kubota0Shogo Sugaki1Erika Komori2Reiko Watanabe3Yuki Higuchi4Yukikazu Harada5Hiroyuki Hashimoto6Shinobu Fujimura7Motoni Kadowaki8Faculty of Engineering, Niigata Institute of Technology, 1719 Fujihashi, Kashiwazaki, Niigata 945-1195, Japan; Center for Transdisciplinary Research, Niigata University, 8050 Ikarashi 2-no-cho, Nishi-ku, Niigata 950-2181, Japan; Corresponding author at: Faculty of Engineering, Niigata Institute of Technology, 1719 Fujihashi, Kashiwazaki, Niigata 945-1195, Japan.Graduate School of Science and Technology, Niigata University, 8050 Ikarashi 2-no-cho, Nishi-ku, Niigata 950-2181, JapanGraduate School of Science and Technology, Niigata University, 8050 Ikarashi 2-no-cho, Nishi-ku, Niigata 950-2181, JapanDepartment of Health and Nutrition, University of Niigata Prefecture, 471 Ebigase, Higashi-ku, Niigata 950-8680, JapanRice Research Center, Kameda Seika Co., Ltd., 3-1-1 Kameda-kogyodanchi, Kounan-ku, Niigata 950-0198, JapanBasic Research Department, Tsuno Food Industrial Co. Ltd., 94 Shinden, Katsuragi-cho, Ito-gun, Wakayama 649-7194, JapanBasic Research Department, Tsuno Food Industrial Co. Ltd., 94 Shinden, Katsuragi-cho, Ito-gun, Wakayama 649-7194, JapanCenter for Transdisciplinary Research, Niigata University, 8050 Ikarashi 2-no-cho, Nishi-ku, Niigata 950-2181, Japan; Graduate School of Science and Technology, Niigata University, 8050 Ikarashi 2-no-cho, Nishi-ku, Niigata 950-2181, JapanFaculty of Engineering, Niigata Institute of Technology, 1719 Fujihashi, Kashiwazaki, Niigata 945-1195, Japan; Graduate School of Science and Technology, Niigata University, 8050 Ikarashi 2-no-cho, Nishi-ku, Niigata 950-2181, JapanWe investigated whether rice protein ameliorates the osteoporosis associated with type 2 diabetes in Zucker diabetic fatty rats. Diets containing rice endosperm protein, rice bran protein, or casein were fed for 10 weeks. The rats exhibited an early stage of diabetic nephropathy and chronic kidney disease–mineral and bone disorder, and parameters reflecting mineral and bone metabolism and bone structure and strength were evaluated. Feeding casein to Zucker Diabetic Fatty rats increased their serum fibroblast growth factor 23 and parathyroid hormone concentrations, suggesting relative excess phosphorus intake, a low serum osteocalcin concentration, and a slightly elevated serum tartrate-resistant acid phosphatase-5b concentration, indicating bone catabolism. In addition, the microarchitecture and strength of the femur were impaired. However, feeding rice endosperm protein and rice bran protein improved these parameters to near normal. These results imply that feeding these rice proteins causes an amelioration of diabetic osteoporosis.http://www.sciencedirect.com/science/article/pii/S1756464624006509Rice endosperm proteinRice bran proteinDiabetesOsteoporosisZucker Diabetic Fatty rat |
| spellingShingle | Masatoshi Kubota Shogo Sugaki Erika Komori Reiko Watanabe Yuki Higuchi Yukikazu Harada Hiroyuki Hashimoto Shinobu Fujimura Motoni Kadowaki Rice endosperm and bran proteins ameliorate diabetic osteoporosis in Zucker Diabetic Fatty rats Journal of Functional Foods Rice endosperm protein Rice bran protein Diabetes Osteoporosis Zucker Diabetic Fatty rat |
| title | Rice endosperm and bran proteins ameliorate diabetic osteoporosis in Zucker Diabetic Fatty rats |
| title_full | Rice endosperm and bran proteins ameliorate diabetic osteoporosis in Zucker Diabetic Fatty rats |
| title_fullStr | Rice endosperm and bran proteins ameliorate diabetic osteoporosis in Zucker Diabetic Fatty rats |
| title_full_unstemmed | Rice endosperm and bran proteins ameliorate diabetic osteoporosis in Zucker Diabetic Fatty rats |
| title_short | Rice endosperm and bran proteins ameliorate diabetic osteoporosis in Zucker Diabetic Fatty rats |
| title_sort | rice endosperm and bran proteins ameliorate diabetic osteoporosis in zucker diabetic fatty rats |
| topic | Rice endosperm protein Rice bran protein Diabetes Osteoporosis Zucker Diabetic Fatty rat |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624006509 |
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