Development of fatty acid analogues with potent anabolic effects on bone in male mice

Natural fatty acids are inhibitory to osteoclastogenesis, but only mildly so, as reported earlier by our and other groups. To improve the potency, we have synthesized two categories of analogues based on the backbone of saturated palmitic acid by inserting an ether or a triazole group in the carbon...

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Bibliographic Details
Main Authors: Jian-ming Lin, Ivo Dimitrov, Karen E. Callon, Maureen Watson, Ian R. Reid, William A. Denny, Jillian Cornish
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Bone Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2352187225000397
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